*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AY3850000
CHEMICAL NAME           : Alanine,
                          3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-, L-
CAS REGISTRY NUMBER     : 35849-41-3
OTHER CAS REGISTRY NOS. : 32526-17-3
LAST UPDATED            : 199706
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C14-H18-Cl2-N2-O3
MOLECULAR WEIGHT        : 333.24
WISWESSER LINE NOTATION : QVYMVH1R DN2G2G  -L
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-N-formyl-, (-)-
   * L-3-(p-(Bis(2-chloroethyl)amino)phenyl)-N-formylalanine
   * CB 3208
   * N-Formylmelphalan
   * N-Formyl-L-p-sarcolysin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AICCA6 Acta Unio Internationalis Contra Cancrum.  (Louvain, Belgium) V.1-20,
   1936-64.  For publisher information, see IJCNAW. Volume(issue)/page/year:
   20,144,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AICCA6 Acta Unio Internationalis Contra Cancrum.  (Louvain, Belgium) V.1-20,
   1936-64.  For publisher information, see IJCNAW. Volume(issue)/page/year:
   20,144,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 730 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AICCA6 Acta Unio Internationalis Contra Cancrum.  (Louvain, Belgium) V.1-20,
   1936-64.  For publisher information, see IJCNAW. Volume(issue)/page/year:
   20,144,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AICCA6 Acta Unio Internationalis Contra Cancrum.  (Louvain, Belgium) V.1-20,
   1936-64.  For publisher information, see IJCNAW. Volume(issue)/page/year:
   20,144,1964
 
                            *** END OF RECORD ***