*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : AY4025000 CHEMICAL NAME : Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, monohydrochloride, L- CAS REGISTRY NUMBER : 3223-07-2 LAST UPDATED : 199706 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C13-H18-Cl2-N2-O2.Cl-H MOLECULAR WEIGHT : 341.69 WISWESSER LINE NOTATION : QVYZ1R DN2G2G &GH -L COMPOUND DESCRIPTOR : Tumorigen Human SYNONYMS/TRADE NAMES : * L-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride * Alanine nitrogen mustard hydrochloride * L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine monohydrochloride * Melphalan hydrochloride * NSC-8806 * L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride * Phenylalanine mustard hydrochloride * L-Phenylalanine mustard hydrochloride * L-Sarcolysine hydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 1200 ug/kg/5D-I TOXIC EFFECTS : Gastrointestinal - nausea or vomiting REFERENCE : CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 57,369,1973 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 430 ug/kg TOXIC EFFECTS : Blood - leukopenia Blood - thrombocytopenia Blood - other changes REFERENCE : CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 430 ug/kg TOXIC EFFECTS : Blood - leukopenia Blood - agranulocytosis Blood - other changes REFERENCE : CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1300 ug/kg/4W TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 36,915,1966 *** END OF RECORD ***