*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AY4025000
CHEMICAL NAME           : Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,
                          monohydrochloride, L-
CAS REGISTRY NUMBER     : 3223-07-2
LAST UPDATED            : 199706
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C13-H18-Cl2-N2-O2.Cl-H
MOLECULAR WEIGHT        : 341.69
WISWESSER LINE NOTATION : QVYZ1R DN2G2G &GH -L
COMPOUND DESCRIPTOR     : Tumorigen
                          Human
SYNONYMS/TRADE NAMES :
   * L-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride
   * Alanine nitrogen mustard hydrochloride
   * L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine monohydrochloride
   * Melphalan hydrochloride
   * NSC-8806
   * L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride
   * Phenylalanine mustard hydrochloride
   * L-Phenylalanine mustard hydrochloride
   * L-Sarcolysine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 1200 ug/kg/5D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   CCROBU Cancer Chemotherapy Reports, Part 1.  (Washington, DC)  V.52(6)-59,
   1968-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   57,369,1973
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 430 ug/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - thrombocytopenia
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,201,1965
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 430 ug/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - agranulocytosis
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,201,1965
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1300 ug/kg/4W
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   36,915,1966
 
                            *** END OF RECORD ***