*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : AY4343000 CHEMICAL NAME : Alanine, N-carboxy-3-phenyl-, N-benzyl ester, L- CAS REGISTRY NUMBER : 1161-13-3 LAST UPDATED : 199206 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C17-H17-N-O4 MOLECULAR WEIGHT : 299.35 COMPOUND DESCRIPTOR : Reproductive Effector SYNONYMS/TRADE NAMES : * (Benzyloxycarbonyl)phenylalanine * Carbobenzoxyphenylalanine * Carbobenzoxy-L-phenylalanine * N-Carbobenzoxy-L-phenylalanine * L-N-Carboxy-3-phenylalanine N-benzyl ester * L-Phenylalanine, N-((phenylmethoxy)carbonyl)- * N-((Phenylmethoxy)carbonyl)-L-phenylalanine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 251 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1726,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravaginal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 280 mg/kg SEX/DURATION : female 28 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal SPECIES OBSERVED : Rodent - mouse DOSE : 280 mg/kg SEX/DURATION : female 28 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 *** END OF RECORD ***