*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AY6031000
CHEMICAL NAME           : Alanine, 3,3'-diselenodi-, DL-
CAS REGISTRY NUMBER     : 2897-21-4
LAST UPDATED            : 199712
DATA ITEMS CITED        : 27
MOLECULAR FORMULA       : C6-H12-N2-O4-Se2
MOLECULAR WEIGHT        : 334.12
WISWESSER LINE NOTATION : QVYZ1-SE--SE-1YZVQ
SYNONYMS/TRADE NAMES :
   * Seleno-DL-cystine
   * D,L-Selenocystine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8463 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 108,437,1953
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   45,207,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 76 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJTHEC Japanese Journal of Toxicology and Environmental Health.  (Nippon
   Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.38-    1992-
   Volume(issue)/page/year: 39,289,1993
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 900 mg/kg/90D-I
TOXIC EFFECTS :
   Blood - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   68,91,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg/30D-I
TOXIC EFFECTS :
   Liver - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   JJTHEC Japanese Journal of Toxicology and Environmental Health.  (Nippon
   Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.38-    1992-
   Volume(issue)/page/year: 39,289,1993

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.2 mg(Se)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.2 mg(Se)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   3,224,1971

   OSHA PEL (Gen Indu):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-AUSTRALIA:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-BELGIUM:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-DENMARK:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-FINLAND:TWA 0.1 mg(Se)/m3;STEL 0.3 mg(Se)/m3 JAN 1993
   
   OEL-GERMANY:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-HUNGARY:STEL 0.1 mg(Se)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-POLAND:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-TURKEY:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

 
                            *** END OF RECORD ***