*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : AY6310000 CHEMICAL NAME : Alanine, 3-(p-fluorophenyl)- CAS REGISTRY NUMBER : 60-17-3 LAST UPDATED : 199709 DATA ITEMS CITED : 15 MOLECULAR FORMULA : C9-H10-F-N-O2 MOLECULAR WEIGHT : 183.20 WISWESSER LINE NOTATION : QVYZ1R DF COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * p-Fluorophenylalanine * 4-Fluorophenylalanine * Phenylalanine, 4-fluoro- *** HEALTH HAZARD DATA *** ** MUTATION DATA ** TYPE OF TEST : DNA damage TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 1 mmol/L REFERENCE : JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year: 96,939,1968 TYPE OF TEST : DNA inhibition TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 1 mmol/L REFERENCE : JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year: 96,939,1968 TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 10 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 12,349,1971 TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Mold - Neurospora crassa DOSE/DURATION : 1 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 167,35,1986 TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 500 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 53,248,1978 TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 300 mg/L REFERENCE : EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 31,97,1979 TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Mold - Aspergillus nidulans DOSE/DURATION : 36 mg/L REFERENCE : EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 31,81,1979 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human HeLa cell DOSE/DURATION : 200 umol/L REFERENCE : ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 92,211,1975 TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 100 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 164,117,1986 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 5 mmol/L REFERENCE : ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 89,431,1974 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: Aspergillus-aneuploidy; N crassa-aneuploidy EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S cerevisiae-aneuploidy EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion EPA GENETOX PROGRAM 1988, Negative: Aspergillus-recombination *** END OF RECORD ***