*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NM3150000 CHEMICAL NAME : Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogen phosphate CAS REGISTRY NUMBER : 520-52-5 BEILSTEIN REFERENCE NO. : 0273158 REFERENCE : 4-22-00-05665 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C12-H17-N2-O4-P MOLECULAR WEIGHT : 284.28 WISWESSER LINE NOTATION : T56 BMJ D2N1&1 FOPQQO COMPOUND DESCRIPTOR : Drug Mutagen Human SYNONYMS/TRADE NAMES : * CY-39 * 3-(2-(Dimethylamino)ethyl)-1H-indol-4-ol dihydrogen phosphate ester * 3-2'-Dimethylaminoethylindol-4-phosphate * 3-(2-Dimethylaminoethyl)indol-4-yl dihydrogen phosphate * Indocybin * O-Phosphoryl-4-hydroxy-N,N-dimethyltryptamine * 4-Phosphoryloxy-omega-N,N-dimethyltryptamine * Psilocibin * Psilocin phosphate ester * Psilocybin * Psilotsibin * Psilocybine * Teonanacatl *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human DOSE/DURATION : 75 ug/kg TOXIC EFFECTS : Behavioral - euphoria Behavioral - hallucinations, distorted perceptions REFERENCE : PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 3,219,1962 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 60 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - visual field changes Behavioral - muscle weakness Gastrointestinal - nausea or vomiting REFERENCE : JNMDAN Journal of Nervous and Mental Disease. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.3- 1876- Volume(issue)/page/year: 131,428,1960 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Human DOSE/DURATION : 37 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - visual field changes Behavioral - muscle weakness Gastrointestinal - nausea or vomiting REFERENCE : JNMDAN Journal of Nervous and Mental Disease. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.3- 1876- Volume(issue)/page/year: 131,428,1960 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human DOSE/DURATION : 130 ug/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 8,59,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,138,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 420 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,159,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 275 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,159,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 13 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,138,1972 ** MUTATION DATA ** TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Unreported TEST SYSTEM : Human DOSE/DURATION : 229 ug/kg REFERENCE : HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For publisher information, see HUGEDQ. Volume(issue)/page/year: 9,281,1970 *** REVIEWS *** TOXICOLOGY REVIEW JMTHBU Journal of the Medical Association of Thailand. (Businesss Mgr., Dept. of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok 7, Thailand) V.1- 1918- Volume(issue)/page/year: 58,623,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7177 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1358 (estimated) No. of Female Employees: 956 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus *** END OF RECORD ***