*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM3150000
CHEMICAL NAME           : Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogen
                          phosphate
CAS REGISTRY NUMBER     : 520-52-5
BEILSTEIN REFERENCE NO. : 0273158
REFERENCE               : 4-22-00-05665 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C12-H17-N2-O4-P
MOLECULAR WEIGHT        : 284.28
WISWESSER LINE NOTATION : T56 BMJ D2N1&1 FOPQQO
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * CY-39
   * 3-(2-(Dimethylamino)ethyl)-1H-indol-4-ol dihydrogen phosphate ester
   * 3-2'-Dimethylaminoethylindol-4-phosphate
   * 3-(2-Dimethylaminoethyl)indol-4-yl dihydrogen phosphate
   * Indocybin
   * O-Phosphoryl-4-hydroxy-N,N-dimethyltryptamine
   * 4-Phosphoryloxy-omega-N,N-dimethyltryptamine
   * Psilocibin
   * Psilocin phosphate ester
   * Psilocybin
   * Psilotsibin
   * Psilocybine
   * Teonanacatl
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human
DOSE/DURATION           : 75 ug/kg
TOXIC EFFECTS :
   Behavioral - euphoria
   Behavioral - hallucinations, distorted perceptions
REFERENCE :
   PSYPAG Psychopharmacologia (Berlin).  (Berlin, Ger.)  V.1-46, 1959-76.  For
   publisher information, see PSCHDL.  Volume(issue)/page/year: 3,219,1962
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 60 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - visual field changes
   Behavioral - muscle weakness
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JNMDAN Journal of Nervous and Mental Disease.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.3-    1876- Volume(issue)/page/year:
   131,428,1960
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Human
DOSE/DURATION           : 37 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - visual field changes
   Behavioral - muscle weakness
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JNMDAN Journal of Nervous and Mental Disease.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.3-    1876- Volume(issue)/page/year:
   131,428,1960
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human
DOSE/DURATION           : 130 ug/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - toxic psychosis
REFERENCE :
   PSDTAP Proceedings of the European Society for the Study of Drug Toxicity.
   (Princeton, NJ 08540) V.1-15, 1963-74.  For publisher information, see
   PESTD5.  Volume(issue)/page/year: 8,59,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,138,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   64,159,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   64,159,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 13 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,138,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Human
DOSE/DURATION           : 229 ug/kg
REFERENCE :
   HUMAA7 Humangenetik.  (Heidelberg, Fed. Rep. Ger.)  V.1-30, 1964-75.  For
   publisher information, see HUGEDQ.  Volume(issue)/page/year: 9,281,1970

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   JMTHBU Journal of the Medical Association of Thailand.  (Businesss Mgr.,
   Dept. of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok 7,
   Thailand)  V.1-    1918-  Volume(issue)/page/year: 58,623,1975

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X7177
       No. of Facilities: 25 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 1358 (estimated)
       No. of Female Employees: 956 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus

 
                            *** END OF RECORD ***