*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM3325000
CHEMICAL NAME           : Indol-4(5H)-one,
                          3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 15622-65-8
LAST UPDATED            : 199707
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C16-H24-N2-O2.Cl-H
MOLECULAR WEIGHT        : 312.88
WISWESSER LINE NOTATION : T56 BM FV&TJ C1 D2 G1- AT6N DOTJ &GH
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * EN-1733A
   * 3-Ethyl-6,7-dihydro-2-methyl-5-morpholinomethylindole-4(5H)-one  
   hydrochloride
   * 3-Ethyl-6,7-dihydro-2-methyl-5-morpholinomethylindol-4(5H)-one  
   hydrochloride
   * Lidone
   * Moban
   * Molindone hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 4762 ug/kg/3D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Musculoskeletal - other changes
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/year: 47,607,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 261 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 670 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 26,738,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 243 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,134,1972
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE                    : 2500 ug/kg
SEX/DURATION            : male 2 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   TXMDAX Texas Medicine.  (Texas Medical Assoc., 1801 N. Lamar Blvd., Austin,
   TX 78701)  V.60-    1964-  Volume(issue)/page/year: 81(9),47,1985

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5639
       No. of Facilities: 33 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 667 (estimated)
       No. of Female Employees: 333 (estimated)

 
                            *** END OF RECORD ***