*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM3330000
CHEMICAL NAME           : 4H-Indol-4-one,
                          1,5,6,7-tetrahydro-5-(1,4-dioxa-8-azaspiro(4.5)dec-8-
                          ylmethyl)-3-ethyl-2- methyl-
CAS REGISTRY NUMBER     : 25331-92-4
BEILSTEIN REFERENCE NO. : 1155952
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H28-N2-O3
MOLECULAR WEIGHT        : 332.49
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AL-1612
   *   3-Ethyl-5-(4,4-ethylenedioxypiperidino-1-methyl)-6,7-dihydro-2-methylind
     ol-4(5H)-one
   * Indol-4(5H)-one,  
   5-(1,4-dioxa-8-azaspiro(4.5)dec-8-ylmethyl)-3-ethyl-6,7-dihydro-2-methyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1314,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1314,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1314,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1314,1973
 
                            *** END OF RECORD ***