*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM7524000
CHEMICAL NAME           : D-myo-Inositol,
                          O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopy
                          anosyl-(1-1)-O-(2,6-
                          diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enop
                          yranosyl-(1-3))-4,6-d iamino-4,5,6- trideoxy-,
                          sulfate
CAS REGISTRY NUMBER     : 68231-64-1
LAST UPDATED            : 199709
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C19-H37-N5-O7.H2-O4-S
MOLECULAR WEIGHT        : 545.69
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 5-Episisomicin sulfate
   * Mutamycin 6 sulfate
   * Pentisomicin sulfate
   * Sch 22591 sulfate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 213 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 13,41,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 256 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 13,41,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 13,41,1978
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1365 mg/kg/7D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes primarily in glomeruli
   Kidney, Ureter, Bladder - other changes in urine composition
   Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 13,41,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 731 mg/kg/15D-I
TOXIC EFFECTS :
   Behavioral - ataxia
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 13,41,1978
 
                            *** END OF RECORD ***