*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM8895500
CHEMICAL NAME           : Insulin (human), 28b-L-lysine-29b-L-proline-
CAS REGISTRY NUMBER     : 133107-64-9
LAST UPDATED            : 199506
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C257-H383-N65-O77-S6
MOLECULAR WEIGHT        : 5808.41
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Insulin lispro
   * Insulin (ox),  
   8a-L-threonine-10a-L-isoleucine-28b-L-lysine-29b-L-proline-30b-L-threoni  
   ne
   * LY 275585
   * 28b-L-Lysine-29b-L-proline insulin (human)
   * (Lys(B28),pro(B29))-human insulin
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 940 units/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 13,247,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 55 units/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 13,247,1994
 
                            *** END OF RECORD ***