*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM8912800
CHEMICAL NAME           : Insulin protamine zinc
CAS REGISTRY NUMBER     : 9004-17-5
LAST UPDATED            : 199706
DATA ITEMS CITED        : 6
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Depo-insulin
   * Deposulin
   * Insulin retard RI
   * Insulin zinc protaminate
   * Insulin zinc protamine
   * Insulyl-retard
   * I.P.Z.
   * Isophane insulin
   * Isophane insulin suspension
   * NPH insulin
   * NPH 50 insulin
   * Protamine zinc insulin
   * Protamine zinc insulin injection
   * Protamine zinc insulin suspension
   * Zinc protamine insulin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 830 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Endocrine - hypoglycemia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   4,631,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 195 iu/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 153,379,1965
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1458 ug/kg
SEX/DURATION            : female 15-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   DIAEAZ Diabetes.  (American Diabetes Assoc., 2 Park Ave., New York, NY
   10016)  V.1-    1952-  Volume(issue)/page/year: 13,44,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 42 iu/kg
SEX/DURATION            : female 14-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
   Reproductive - Effects on Newborn - behavioral
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   DBRRDB Developmental Brain Research.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1981-  Volume(issue)/page/year:
   88,127,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 167 ug/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ANREAK Anatomical Record.  (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
   10003)  V.1-    1906/08-  Volume(issue)/page/year: 124,441,1956

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X6062
       No. of Facilities: 7 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 628 (estimated)
       No. of Female Employees: 314 (estimated)

 
                            *** END OF RECORD ***