*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NM9700725
CHEMICAL NAME : Interferon-gamma (human lymphocyte protein moiety
reduced)
CAS REGISTRY NUMBER : 82115-62-6
LAST UPDATED : 199712
DATA ITEMS CITED : 3
COMPOUND DESCRIPTOR : Drug
Natural Product
SYNONYMS/TRADE NAMES :
* OH-6000
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 10000 ku/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Blood - changes in leukocyte (WBC) count
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 22,283,1994
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : >50000 ku/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in leukocyte (WBC) count
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 22,269,1994
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 1680 ku/kg/28D-I
TOXIC EFFECTS :
Blood - changes in spleen
Related to Chronic Data - changes in testicular weight
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 22,303,1994
*** END OF RECORD ***