*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NM9740000
CHEMICAL NAME           : Interleukin-1-beta
LAST UPDATED            : 199706
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 22500 mg/kg
SEX/DURATION            : female 17-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NUNDAJ Neuroendocrinology.  (S. Karger AG, Postfach CH-4009 Basel,
   Switzerland)  V.1-    1965/66-  Volume(issue)/page/year: 58,344,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 22500 mg/kg
SEX/DURATION            : female 17-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NUNDAJ Neuroendocrinology.  (S. Karger AG, Postfach CH-4009 Basel,
   Switzerland)  V.1-    1965/66-  Volume(issue)/page/year: 58,344,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 640 ug/kg
SEX/DURATION            : female 3 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   SCYYDZ Shengzhi Yu Biyun.  Reproduction and Contraception.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
    Volume(issue)/page/year: 14,92,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 640 ug/kg
SEX/DURATION            : female 4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   SCYYDZ Shengzhi Yu Biyun.  Reproduction and Contraception.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
    Volume(issue)/page/year: 14,92,1994
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 250 pg/L
REFERENCE :
   ECREAL Experimental Cell Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.10-    1950-  Volume(issue)/page/year: 179,488,1988
 
                            *** END OF RECORD ***