*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NO1700000
CHEMICAL NAME           : Ipecac syrup
CAS REGISTRY NUMBER     : 8012-96-2
OTHER CAS REGISTRY NOS. : 8052-61-7
LAST UPDATED            : 199504
DATA ITEMS CITED        : 10
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * Ipecacuanha
   * Syrup of ipecac, U.S.P
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 214 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Gastrointestinal - nausea or vomiting
REFERENCE :
   SMJOAV Southern Medical Journal.  (Southern Medical Assoc., POB 2446,
   Birmingham, AL 35205) V.1-    1908-  Volume(issue)/page/year: 77,804,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 65,1398,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 113 mg/kg/13W-C
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Cardiac - change in rate
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   243,1927,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   36THAV "Management of the Poisoned Patient," Rumack, B.H., and A.R. Temple,
   eds., Princeton, NJ, Science Press, 1977  Volume(issue)/page/year:
   -,175,1977
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - ulceration or bleeding from small intestine
   Gastrointestinal - nausea or vomiting
REFERENCE :
   36THAV "Management of the Poisoned Patient," Rumack, B.H., and A.R. Temple,
   eds., Princeton, NJ, Science Press, 1977  Volume(issue)/page/year:
   -,175,1977

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 10,221,1977

   TOXICOLOGY REVIEW
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 12,601,1978

   TOXICOLOGY REVIEW
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 10,221,1977

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80594
       No. of Facilities: 1101 (estimated)
       No. of Industries: 3
       No. of Occupations: 9
       No. of Employees: 11391 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80594
       No. of Facilities: 41 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 1098 (estimated)
       No. of Female Employees: 672 (estimated)

 
                            *** END OF RECORD ***