*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NO4565500
CHEMICAL NAME           : Iron
CAS REGISTRY NUMBER     : 7439-89-6
LAST UPDATED            : 199712
DATA ITEMS CITED        : 17
MOLECULAR FORMULA       : Fe
MOLECULAR WEIGHT        : 55.85
COMPOUND DESCRIPTOR     : Tumorigen
                          Human
SYNONYMS/TRADE NAMES :
   * Ancor en 80/150
   * Armco iron
   * Carbonyl iron
   * EFV 250/400
   * EO 5A
   * Ferrovac E
   * GS 6
   * LOHA
   * NC 100
   * PZh2M
   * PZhO
   * Remko
   * SUY-B 2
   * 3ZhP
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 77 mg/kg
TOXIC EFFECTS :
   Behavioral - irritability
   Gastrointestinal - nausea or vomiting
   Blood - normocytic anemia
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   25,251,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 gm/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   IJPAAO Indian Journal of Pharmacy.  (Bombay, India)  V.1-40(1), 1939-78. For
   publisher information, see IJSIDW.  Volume(issue)/page/year: 13,240,1951
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB158-508
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 20 gm/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   IJPAAO Indian Journal of Pharmacy.  (Bombay, India)  V.1-40(1), 1939-78. For
   publisher information, see IJSIDW.  Volume(issue)/page/year: 13,240,1951
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/m3/6H/4W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   145,10,1997
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 450 mg/kg/15W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   SAIGBL Sangyo Igaku.  Japanese Journal of Industrial Health.  (Nippon Sangyo
   Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
   Japan)  V.1-    1959-  Volume(issue)/page/year: 16,380,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 91095
       No. of Facilities: 13096 (estimated)
       No. of Industries: 160
       No. of Occupations: 115
       No. of Employees: 207672 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - T0176
       No. of Facilities: 13865 (estimated)
       No. of Industries: 130
       No. of Occupations: 72
       No. of Employees: 204603 (estimated)
       No. of Female Employees: 16574 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X3724
       No. of Facilities: 122 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 1670 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5910
       No. of Facilities: 3 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 400 (estimated)
       No. of Female Employees: 400 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5996
       No. of Facilities: 45 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 179 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 91095
       No. of Facilities: 103949 (estimated)
       No. of Industries: 364
       No. of Occupations: 174
       No. of Employees: 1312446 (estimated)
       No. of Female Employees: 116899 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NIOSH Analytical Method, 1994: Metals in urine, 8310
   
   NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005

 
                            *** END OF RECORD ***