*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NO6725000
CHEMICAL NAME           : Iron, (dihydrogen
                          3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipro
                          pionato(2-))-hydroxy-
CAS REGISTRY NUMBER     : 15489-90-4
LAST UPDATED            : 199106
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C34-H31-Fe-N4-O5.2H
MOLECULAR WEIGHT        : 633.56
COMPOUND DESCRIPTOR     : Drug
                          Organometallic
                          Human
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Bovine hemin
   * Ferrihemate
   * Ferriheme
   * Ferriheme hydroxide
   * Ferrihemic acid
   * Ferriporphyrin hydroxide
   * Ferriprotoporphyrin basic
   * Ferriprotoporphyrin IX hydroxide
   * Hematin
   * Hydroxy(dihydrogen protoporphyrin IX-ato(2-))iron
   * Hydroxyhemin
   * Phenodin
   * Protohematin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 40 mg/kg/30D-I
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP elevation not characterized in autonomic section
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   101,877,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 43 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - hemorrhage
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 2,329,1978
 
                            *** END OF RECORD ***