*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NO7400000 CHEMICAL NAME : Iron(III) oxide CAS REGISTRY NUMBER : 1309-37-1 OTHER CAS REGISTRY NOS. : 8011-97-0 LAST UPDATED : 199712 DATA ITEMS CITED : 44 MOLECULAR FORMULA : Fe2-O3 MOLECULAR WEIGHT : 159.70 WISWESSER LINE NOTATION : FE2 O3 COMPOUND DESCRIPTOR : Tumorigen SYNONYMS/TRADE NAMES : * Anchred standard * Anhydrous iron oxide * Anhydrous oxide of iron * Armenian bole * Bauxite residue * Black oxide of iron * Blended red oxides of iron * Burntisland Red * Burnt umber * Calcotone Red * Caput mortuum * Colcothar * Colloidal ferric oxide * C.I. 77491 * C.I. Pigment Red 101 * C.I. Pigment Red 102 * C.I. Pigment Red 101 and 102 * Crocus martis adstringens * Deanox * Deanox DNX Pigments * Eisenoxyd * English Red * Ferric oxide * Ferric oxide (colloidal) * Ferrugo * Iron oxide * Iron Oxide Red * Iron oxide pigments * Iron Red * Iron sesquioxide * Jeweler's rouge * Levanox Red 130A * Light Red * Manufactured iron oxides * Mars Brown * Mars Red * Natural iron oxides * Natural Red Oxide * Ochre * Prussian Brown * Quick rouge * Raddle * 11554 Red * Red Iron Oxide * Red ochre * Red oxide * Red oxide D3452 * Red oxide D6984 * Red oxide of iron * Rouge * Rubigo * Sienna * Specular iron * Stone Red * Supra * Synthetic iron oxide * Venetian Red * Vitriol Red * Vogel's Iron Red * Yellow ferric oxide * Yellow oxide of iron *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 ug/m3/24H/61D-C TOXIC EFFECTS : Brain and Coverings - other degenerative changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(7),73,1985 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 135 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965- Volume(issue)/page/year: 14,47,1978 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3, Inhalable dust DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal NO EVIDENCE IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,29,1972 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,29,1972 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,216,1987 TOXICOLOGY REVIEW ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 78,99,1972 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:NUISANCE PARTICULATES DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,27,1973 OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 3 ppm (5 mg/m3) (fume) JAN 1993 OEL-AUSTRALIA:TWA 5 mg/m3 (fume) JAN 1993 OEL-BELGIUM:TWA 2 ppm (5 mg/m3) (fume) JAN 1993 OEL-DENMARK:TWA 3.5 mg/m3 (fume) JAN 1993 OEL-FINLAND:TWA 5 ppm (fume) JAN 1993 OEL-FRANCE:TWA 5 mg/m3 (fume) JAN 1993 OEL-GERMANY:TWA 6 mg/m3 (fume) JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3 (fume) JAN 1993 OEL-THE PHILIPPINES:TWA 10 mg/m3 (fume) JAN 1993 OEL-POLAND:TWA 5 mg/m3 (fume) JAN 1993 OEL-SWEDEN:TWA 3.5 mg/m3 (fume) JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (5 mg/m3) (fume) JAN 1993 OEL-THAILAND:TWA 10 mg/m3 (fume) JAN 1993 OEL-TURKEY:TWA 10 mg/m3 (fume) JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3 (total dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 (fume) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO IRON OXIDE, dust and fume (as Fe)-air:10H TWA 5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1463 No. of Facilities: 41132 (estimated) No. of Industries: 265 No. of Occupations: 153 No. of Employees: 483117 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1463 No. of Facilities: 62557 (estimated) No. of Industries: 308 No. of Occupations: 185 No. of Employees: 965275 (estimated) No. of Female Employees: 139397 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NIOSH Analytical Method, 1994: Elements by ICP, 7300 OSHA ANALYTICAL METHOD #ID-125G *** END OF RECORD ***