*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NQ4025000
CHEMICAL NAME           : Isobutyraldehyde
CAS REGISTRY NUMBER     : 78-84-2
LAST UPDATED            : 199806
DATA ITEMS CITED        : 13
MOLECULAR FORMULA       : C4-H8-O
MOLECULAR WEIGHT        : 72.12
WISWESSER LINE NOTATION : VHY1&1
COMPOUND DESCRIPTOR     : Tumorigen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Isobutaldehyde
   * Isobutanal
   * Isobutyral
   * Isobutyraldehyd
   * Isobutyric aldehyde
   * Isobutyryl aldehyde
   * Isopropyl aldehyde
   * Isopropyl formaldehyde
   * Methyl propanal
   * 2-Methylpropanal
   * 2-Methyl-1-propanal
   * alpha-Methylpropionaldehyde
   * 2-Methylpropionaldehyde
   * NCI-C60968
   * Propanal, 2-methyl-
   * Propionaldehyde, 2-methyl-
   * Valine aldehyde
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Open irritation test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 397 mg
REACTION SEVERITY       : Mild
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 11/3/1971
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 960 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - necrotic changes
   Blood - hemorrhage
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 37(5),104,1972
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 10,61,1954
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 39500 mg/m3/2H
TOXIC EFFECTS :
   Behavioral - excitement
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Lungs, Thorax, or Respiration - pleural thickening
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 37(5),104,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 7130 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 10,61,1954

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84782
       No. of Facilities: 21 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 705 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 84782
       No. of Facilities: 32 (estimated)
       No. of Industries: 3
       No. of Occupations: 2
       No. of Employees: 4114 (estimated)
       No. of Female Employees: 655 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
   
   NTP Carcinogenesis studies; test completed (post peer review), October 1997

 
                            *** END OF RECORD ***