*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NR3538000
CHEMICAL NAME           : 5-Isoindolinesulfonamide,
                          6-chloro-2-cyclohexyl-3-oxo-
CAS REGISTRY NUMBER     : 2127-01-7
BEILSTEIN REFERENCE NO. : 0493411
REFERENCE               : 5-22-07-00591 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C14-H17-Cl-N2-O3-S
MOLECULAR WEIGHT        : 328.84
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Chlorexolone
   * 5-Chloro-2-cyclohexyl-1-oxo-6-sulphamoylisoindoline
   * Clorexolon
   * Clorexolone
   * Flonatril
   * 1H-Isoindole-5-sulfonamide, 2,3-dihydro-6-chloro-2-cyclohexyl-3-oxo-
   * Klorex
   * M & B 8430
   * Nefrolan
   * 12833 R.P.
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 21,775,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 18,65,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,257,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 560 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory stimulation
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   BFPHA8 Bulletin of the Faculty of Pharmacy (Cairo University).  (Faculty of
   Pharmacy, Cairo Univ., Cairo, Egypt)  V.1-    1961/62-
   Volume(issue)/page/year: 10,155,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 18,65,1966
 
                            *** END OF RECORD ***