*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NR3890000
CHEMICAL NAME           : 1H-Isoindol-1-one,
                          2-ethyl-2,3-dihydro-3-((4-(2-(1-piperidinyl)ethoxy)ph
                          enyl)amino)-, mixt. with
                          3,4,5,6-tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazo
                          cine hydrochloride
CAS REGISTRY NUMBER     : 80286-26-6
LAST UPDATED            : 198610
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C23-H29-N3-O2.C17-H19-N-O.Cl-H
MOLECULAR WEIGHT        : 669.38
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acupan mixed with amidoline (5:1)
   * Ajan compd. with etomidoline (5:1)
   * Amidoline compd. with acupan (1:5)
   * Etomidoline combined with ajan (1:5)
   * Etomidoline mixed with nefopam hydrochloride (1:5)
   * K 2680 compd. with nefopam hydrochloride (1:5)
   * Nefopam hydrochloride compd. with etomidoline (5:1)
   * Smedolin mixed with nefopam hydrochloride (1:5)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 132 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - analgesia
REFERENCE :
   YAHOA3 Yakhak Hoe Chi.  Journal of the Pharmaceutical Society.  (Taehan
   Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
   Korea)  V.1-    1956(?)-  Volume(issue)/page/year: 25(1),27,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 49 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - analgesia
REFERENCE :
   YAHOA3 Yakhak Hoe Chi.  Journal of the Pharmaceutical Society.  (Taehan
   Yakkakhoe, c/o College of Pharmacy, Seoul National Univ., Seoul 151, S.
   Korea)  V.1-    1956(?)-  Volume(issue)/page/year: 25(1),27,1981
 
                            *** END OF RECORD ***