*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NR4705000
CHEMICAL NAME           : Isoleucine, L-
CAS REGISTRY NUMBER     : 73-32-5
LAST UPDATED            : 199707
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C6-H13-N-O2
MOLECULAR WEIGHT        : 131.20
WISWESSER LINE NOTATION : QVYZY2&1 -L
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Acetic acid, amino-sec-butyl-
   * 2-Amino-3-methylpentanoic acid, (S-(R*,R*))-
   * alpha-Amino-beta-methylvaleric acid
   * Isoleucine
   * L-Isoleucine
   * Norvaline, 3-methyl-
   * Valeric acid, 2-amino-3-methyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6822 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ABBIA4 Archives of Biochemistry and Biophysics.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.31-    1951-  Volume(issue)/page/year:
   58,253,1955
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4368 mg/kg/13W-C
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - urine volume increased
   Nutritional and Gross Metabolic - changes in sodium
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 47,499,1996
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 372,75,1996

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 5 mg/m3 JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81864
       No. of Facilities: 53 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 750 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81864
       No. of Facilities: 740 (estimated)
       No. of Industries: 3
       No. of Occupations: 13
       No. of Employees: 18202 (estimated)
       No. of Female Employees: 13865 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***