*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NS1926000
CHEMICAL NAME           : Isonicotinic acid, 2-isopropylhydrazide,
                          dihydrochloride
CAS REGISTRY NUMBER     : 6011-62-7
LAST UPDATED            : 199603
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C9-H13-N3-O.2Cl-H
MOLECULAR WEIGHT        : 252.17
WISWESSER LINE NOTATION : T6NJ DVMMY1&1 &GH 2
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Iproniazid dihydrochloride
   * Iproniazid hydrochloride
   * 4-Pyridinecarboxylic acid, 2-(1-methylethyl)hydrazide, dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1470 mg/kg
TOXIC EFFECTS :
   Endocrine - adrenal cortex hypoplasia
   Blood - changes in cell count (unspecified)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   67,511,1960
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1280 mg/kg/13W-C
TOXIC EFFECTS :
   Liver - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in spleen
REFERENCE :
   ARTUA4 American Review of Tuberculosis.  (New York, NY)  V.1-70, 1917-54.
   For publisher information, see ARDSBL.  Volume(issue)/page/year: 65,376,1952
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 195 mg/kg/5D-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - other changes
REFERENCE :
   ARTUA4 American Review of Tuberculosis.  (New York, NY)  V.1-70, 1917-54.
   For publisher information, see ARDSBL.  Volume(issue)/page/year: 65,376,1952
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 910 mg/kg/13W-I
TOXIC EFFECTS :
   Liver - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in spleen
REFERENCE :
   ARTUA4 American Review of Tuberculosis.  (New York, NY)  V.1-70, 1917-54.
   For publisher information, see ARDSBL.  Volume(issue)/page/year: 65,376,1952
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 910 mg/kg/13W-I
TOXIC EFFECTS :
   Liver - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in spleen
REFERENCE :
   ARTUA4 American Review of Tuberculosis.  (New York, NY)  V.1-70, 1917-54.
   For publisher information, see ARDSBL.  Volume(issue)/page/year: 65,376,1952
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6720 mg/kg
SEX/DURATION            : female 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   67,511,1960
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3233 mg/kg
SEX/DURATION            : female 61 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   67,511,1960
 
                            *** END OF RECORD ***