*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NS4900000 CHEMICAL NAME : Isonipecotamide, 1-(3-(2-chlorophenothiazin-10-yl)propyl)- CAS REGISTRY NUMBER : 84-04-8 LAST UPDATED : 199012 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C21-H24-Cl-N3-O-S MOLECULAR WEIGHT : 401.99 WISWESSER LINE NOTATION : T C666 BN ISJ EG B3- AT6NTJ DVZ COMPOUND DESCRIPTOR : Human SYNONYMS/TRADE NAMES : * 1-(3-(3-Chlorophenothiazin-10-yl)propyl)-isonipecotamide * Mometine * Mornidine * Nausidol * Nometine * Pipamazine * SC 8016 * SC 9387 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - somnolence (general depressed activity) Behavioral - coma REFERENCE : 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,478,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 620 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,39,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 370 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,39,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,39,1972 *** REVIEWS *** TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965 *** END OF RECORD ***