*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NS4900000
CHEMICAL NAME           : Isonipecotamide,
                          1-(3-(2-chlorophenothiazin-10-yl)propyl)-
CAS REGISTRY NUMBER     : 84-04-8
LAST UPDATED            : 199012
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C21-H24-Cl-N3-O-S
MOLECULAR WEIGHT        : 401.99
WISWESSER LINE NOTATION : T C666 BN ISJ EG B3- AT6NTJ DVZ
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * 1-(3-(3-Chlorophenothiazin-10-yl)propyl)-isonipecotamide
   * Mometine
   * Mornidine
   * Nausidol
   * Nometine
   * Pipamazine
   * SC 8016
   * SC 9387
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - somnolence (general depressed activity)
   Behavioral - coma
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,478,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,39,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 370 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,39,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,39,1972

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   ARVPAX Annual Review of Pharmacology.  (Palo Alto, CA)  V.1-15, 1961-75. For
   publisher information, see ARPTDI.  Volume(issue)/page/year: 5,447,1965

 
                            *** END OF RECORD ***