*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NS4970000
CHEMICAL NAME           : Isonipecotamide,
                          4-(p-chlorophenyl)-1-(3-(p-fluorobenzoyl)propyl)-N,N-
                          dimethyl-
CAS REGISTRY NUMBER     : 1580-71-8
BEILSTEIN REFERENCE NO. : 0501454
REFERENCE               : 5-22-02-00498 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C24-H28-Cl-F-N2-O2
MOLECULAR WEIGHT        : 430.99
WISWESSER LINE NOTATION : T6NTJ A3VR DF& DVN1&1 DR DG
SYNONYMS/TRADE NAMES :
   * Amiperone
   *   4-(4-Chlorophenyl)-4-(dimethylaminocarbonyl)-1-(3-(4-fluorobenzoyl)propy
     l)piperidine
   *   4-(p-Chlorophenyl)-1-(3-(p-fluorobenzoyl)propyl)-N,N-dimethylisonipecota
     mide
   * Paraperidine
   * Paraperidide
   * R 2962
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,184,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,184,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,184,1972

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   MDCHAG Medicinal Chemistry: A Series of Monographs.  (Academic Press, Inc.,
   1 E. First St., Duluth, MN 55802)  V.1-    1963-  Volume(issue)/page/year:
   4(2),199,1967

 
                            *** END OF RECORD ***