*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NS5075000
CHEMICAL NAME           : Isonipecotamide,
                          1-(3-(2-(methylsulfonyl)phenothiazin-10-yl)propyl)-
CAS REGISTRY NUMBER     : 14008-44-7
OTHER CAS REGISTRY NOS. : 14170-03-7
BEILSTEIN REFERENCE NO. : 4278585
LAST UPDATED            : 199612
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C22-H27-N3-O3-S2
MOLECULAR WEIGHT        : 445.64
WISWESSER LINE NOTATION : T C666 BN ISJ ESW1 B3- AT6NTJ DVZ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * EXP 999
   * 10-(3-(4-Carbamoylpiperidine)propyl)-2-(methanesulfonyl)phenothiazine
   * 2-Methylsulfonyl-10-(3-(4-carbamoylpiperidino)propyl)phenothiazine
   * 1-(3-(2-(Methylsulfonyl)phenothiazin-10-yl)propyl)isonipecotamide
   *   1-(3-(2-(Methylsulfonyl)phenothiazin-10-yl)propyl)-4-piperidinecarboxami
     de
   *   1-(3-(2-(Methylsulfonyl)-10H-phenothiazin-10-yl)propyl)-4-piperidinecarb
     oxamide
   * Metopimazine
   * Phenothiazine, 10-(3-(4'-carbamoylpiperidino)propyl)-2-methylsulfonyl-
   * 4-Piperidinecarboxamide,  
   1-(3-(2-(methanesulfonyl)phenothiazin-10-yl)propyl)-
   * RP 9965
   * Vogalene
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 976 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1080 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
   Sciences Naturelles.  (Paris, France)  V.262-291, 1966-80.  For publisher
   information, see CRASEV.  Volume(issue)/page/year: 266,2365,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 78 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - change in sensation of smell
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 1,97,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 315 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,32,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 64 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - change in sensation of smell
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 1,97,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - tremor
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 11,561,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - tremor
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 11,561,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - ataxia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 11,561,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - ataxia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 11,561,1976
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7500 mg/kg/30D-I
TOXIC EFFECTS :
   Blood - changes in erythrocyte (RBC) count
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 1,97,1967
 
                            *** END OF RECORD ***