*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NS5290000
CHEMICAL NAME           : Isonipecotic acid,
                          1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester
CAS REGISTRY NUMBER     : 915-30-0
BEILSTEIN REFERENCE NO. : 0503374
REFERENCE               : 5-22-02-00487 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C30-H32-N2-O2
MOLECULAR WEIGHT        : 452.64
WISWESSER LINE NOTATION : T6NTJ A2XR&R&CN DVO2 DR
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotic acid ethyl ester
   * Diphenoxylate
   * 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-,  
   ethyl ester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 221 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - decreased motility or constipation
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 16,782,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 337 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 50,1089,1985

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84418
       No. of Facilities: 58 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 230 (estimated)

 
                            *** END OF RECORD ***