*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NS6125000
CHEMICAL NAME           : Isonipecotic acid, 1-(2-morpholinoethyl)-4-phenyl-,
                          ethyl ester, dihydrochloride
LAST UPDATED            : 199512
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C20-H30-N2-O3.2Cl-H
MOLECULAR WEIGHT        : 419.44
WISWESSER LINE NOTATION : T6N DOTJ A2- AT6NTJ DVO2 DR &GH 2
SYNONYMS/TRADE NAMES :
   * Ethyl 1-(2'-morpholinoethyl)-4-phenylpiperidine-4-carboxylate  
   dihydrochloride
   * Morpheridine dihydrochloride
   * Morpholinoethyl norpethidine dihydrochloride
   * 1-(2-Morpholinoethyl)-4-phenylisonipecotic acid ethyl ester  
   dihydrochloride
   * 1-(2-(Morpholinyl)ethyl)-4-phenyl-4-piperidinecarboxylic acid ethyl ester 
    dihydrochloride
   * TA 1
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 11,27,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 118 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - irritability
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 11,27,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - stiffness
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 11,32,1956
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 220 mg/kg/11D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Blood - hemorrhage
   Related to Chronic Data - death
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 11,27,1956
 
                            *** END OF RECORD ***