*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NS6186000
CHEMICAL NAME           : Isonipecotic acid, 1-(2-phenoxyethyl)-4-phenyl-,
                          ethyl ester, hydrobromide
CAS REGISTRY NUMBER     : 18729-31-2
LAST UPDATED            : 199512
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H27-N-O3.Br-H
MOLECULAR WEIGHT        : 434.42
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-(2-Phenoxyethyl)-4-phenylisonipecotic acid ethyl ester hydrobromide
   * TA 27
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 15,247,1960
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 180 mg/kg/12D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Related to Chronic Data - death
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 15,247,1960
 
                            *** END OF RECORD ***