*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NS6270000
CHEMICAL NAME           : Isonipecotic acid,
                          4-phenyl-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-,
                          ethyl ester, hydrochloride
LAST UPDATED            : 199512
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H31-N-O3.Cl-H
MOLECULAR WEIGHT        : 381.99
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-Phenyl-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)isonipecotic acid ethyl  
   ester hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 15,247,1960
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 240 mg/kg/12D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Related to Chronic Data - death
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 15,247,1960
 
                            *** END OF RECORD ***