*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NT2007000
CHEMICAL NAME           : Isophthalic acid
CAS REGISTRY NUMBER     : 121-91-5
BEILSTEIN REFERENCE NO. : 1909332
REFERENCE               : 4-09-00-03292 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C8-H6-O4
MOLECULAR WEIGHT        : 166.14
WISWESSER LINE NOTATION : QVR CVQ
COMPOUND DESCRIPTOR     : Primary Irritant
SYNONYMS/TRADE NAMES :
   * Acide isophtalique
   * Benzene-1,3-dicarboxylic acid
   * m-Benzenedicarboxylic acid
   * Isophthalate
   * Kyselina isoftalova
   * m-Phthalic acid
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,317,1986
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,317,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
   (Paris, France)  V.1-261, 1835-1965.  For publisher information, see CRASEV.
    Volume(issue)/page/year: 246,851,1958

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   BPCT** Progress Report from the Environmental Protection Agency to NIOSH on
   Benzenepolycarboxylates, 1974  Volume(issue)/page/year: -,183,1974

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 0.2 mg/m3;Skin JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 82897
       No. of Facilities: 3665 (estimated)
       No. of Industries: 67
       No. of Occupations: 68
       No. of Employees: 55161 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 82897
       No. of Facilities: 8709 (estimated)
       No. of Industries: 59
       No. of Occupations: 49
       No. of Employees: 117411 (estimated)
       No. of Female Employees: 17858 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***