*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NW7160000 CHEMICAL NAME : Isoquinoline-3-carboxylic acid, 6,7-dimethoxy-1-veratryl-, sodium salt CAS REGISTRY NUMBER : 63905-64-6 LAST UPDATED : 199203 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C21-H20-N-O6.Na MOLECULAR WEIGHT : 405.41 WISWESSER LINE NOTATION : T66 CNJ B1R CO1 DO1& DVO HO1 IO1 &-NA- &36/24 COMPOUND DESCRIPTOR : Human SYNONYMS/TRADE NAMES : * 1-(3,4)-Dimethoxybenzyl-6,7-dimethoxyisoquinoline-3-carboxylic acid, sodium salt * Papaverin carboxylic acid, sodium salt *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 8250 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - muscle contraction or spasticity REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 213,30,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 260 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 213,30,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 225 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 213,30,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 213,30,1951 *** END OF RECORD ***