*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX5014000
CHEMICAL NAME           : Isoquinoline,
                          1,2,3,4-tetrahydro-6,7-diethoxy-1-((3,4-diethoxypheny
                          l)methylene)-, hydrochloride
CAS REGISTRY NUMBER     : 985-12-6
LAST UPDATED            : 199606
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C24-H31-N-O4.Cl-H
MOLECULAR WEIGHT        : 434.02
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Drotaverine hydrochloride
   * Drotaverin hydrochloride
   * Drotaverinium chloride
   * Isodihydroperparine hydrochloride
   * Isoquinoline,  
   1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydro-,  
   hydrochloride
   * No-Spa
   * No-Spa hydrochloride
   * 6,7,3',4'-Tetraethoxy-1-benzal-1,2,3,4-tetrahydroisoquinoline  
   hydrochloride
   * Tetraspasmin-Lefa
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4035366
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4035366
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4035366
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4035366
 
                            *** END OF RECORD ***