*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX5017980
CHEMICAL NAME           : Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-,
                          hydrochloride
CAS REGISTRY NUMBER     : 2328-12-3
LAST UPDATED            : 199009
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C11-H15-N-O2.Cl-H
MOLECULAR WEIGHT        : 229.73
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Heliamine hydrochloride
   * 1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 272 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 88,1197,1968
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 62,165,1938
 
                            *** END OF RECORD ***