*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX5070000
CHEMICAL NAME           : Isoquinoline,
                          1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratryl-
                          , (+-)-
CAS REGISTRY NUMBER     : 1699-51-0
LAST UPDATED            : 198209
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C21-H27-N-O4
MOLECULAR WEIGHT        : 357.49
WISWESSER LINE NOTATION : T66 CNT&J B1R CO1 DO1& C1 HO1 IO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (+-)-Laudanosine
   * (+-)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinoline
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 47 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 20,894,1977
 
                            *** END OF RECORD ***