*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX5825000
CHEMICAL NAME           : Isoquinolinium,
                          1,2,3,4-tetrahydro-7-hydroxy-1-((4-hydroxyphenyl)meth
                          yl)-6-methoxy- 2,2-dimethyl-, chloride, (R)-
CAS REGISTRY NUMBER     : 75413-87-5
LAST UPDATED            : 198406
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H24-N-O3.Cl
MOLECULAR WEIGHT        : 349.89
SYNONYMS/TRADE NAMES :
   * Magnocurarine chloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45500 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle weakness
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 2,89,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8430 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle weakness
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 2,89,1953
 
                            *** END OF RECORD ***