*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NX5980000 CHEMICAL NAME : 7-Isoquinolinol, 1,2,3,4-tetrahydro-1,2-dimethyl-6-methoxy-, hydrochloride, (1R)-(-)- CAS REGISTRY NUMBER : 51713-80-5 LAST UPDATED : 199012 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C12-H17-N-O2.Cl-H MOLECULAR WEIGHT : 243.76 WISWESSER LINE NOTATION : T66 CNT&J B1 C1 HO1 IQ &GH -1R(-) SYNONYMS/TRADE NAMES : * (1R)-(-)-1,2-Dimethyl-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride * 7-Isoquinolinol, 1,2-dimethyl-6-methoxy-1,2,3,4-tetrahydro-, hydrochloride, (1R)-(+)- * (R)-(-)-N-Methylisosalsoline hydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,134,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,134,1974 *** END OF RECORD ***