*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NX6000000 CHEMICAL NAME : 6-Isoquinolinol, 1,2,3,4-tetrahydro-7-methoxy-1-methyl-, hydrochloride, (1R)-(+)- CAS REGISTRY NUMBER : 51424-33-0 LAST UPDATED : 199103 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C11-H15-N-O2.Cl-H MOLECULAR WEIGHT : 229.73 WISWESSER LINE NOTATION : T66 CMT&J B1 HQ IO1 &GH -1R(+) SYNONYMS/TRADE NAMES : * (1R)-(+)-6-Hydroxy-7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride * 6-Isoquinolinol, 7-methoxy-1-methyl-1,2,3,4-tetrahydro-, hydrochloride, (1R)-(+)- * (R)-(+)-Salsoline hydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,134,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,134,1974 *** END OF RECORD ***