*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX6020000
CHEMICAL NAME           : 6-Isoquinolinol,
                          1,2,3,4-tetrahydro-7-methoxy-1-methyl-,
                          hydrochloride, hydrate, (1S)-(-)-, (4:1)
CAS REGISTRY NUMBER     : 64047-43-4
LAST UPDATED            : 199103
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C11-H15-N-O2.Cl-H.1/4H2-O
MOLECULAR WEIGHT        : 234.23
WISWESSER LINE NOTATION : T66 CMT&J B1 HQ IO1 &GH &QH -1S(-)
SYNONYMS/TRADE NAMES :
   * (1S)-(-)-6-Hydroxy-7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline  
   hydrochloride
   * (S)-(-)-Salsoline hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,134,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 245 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,134,1974
 
                            *** END OF RECORD ***