*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NX7285000 CHEMICAL NAME : 1-Isotetrandrine CAS REGISTRY NUMBER : 477-57-6 LAST UPDATED : 199709 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C38-H42-N2-O6 MOLECULAR WEIGHT : 622.82 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl- * O,O'-Dimethylobamegine * O,O'-Dimethylstepholine * Isosinomenin A * Isosinomenine A * Isotetrandrine * (+)-Isotetrandrine * O-Methylberbamine * 6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman * (R,S)-Tetrandrine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65(5),176S,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 160 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976 *** END OF RECORD ***