*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NX9150000 CHEMICAL NAME : Isothiocyanic acid, 1,4-phenylenedi- CAS REGISTRY NUMBER : 4044-65-9 BEILSTEIN REFERENCE NO. : 2414340 REFERENCE : 4-13-00-00174 (Beilstein Handbook Reference) LAST UPDATED : 199701 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C8-H4-N2-S2 MOLECULAR WEIGHT : 192.26 WISWESSER LINE NOTATION : SCNR DNCS COMPOUND DESCRIPTOR : Drug Human SYNONYMS/TRADE NAMES : * Biscomate * Bitoscanate * 1,4-Diisothiocyanatobenzene * Isothiocyanic acid p-phenylene ester * Jonit * Phenylene-1,4-diisothiocyanate * Phenylene thiocyanate *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 3 mg/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting REFERENCE : JTMHA9 Journal of Tropical Medicine and Hygiene. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.10- 1907- Volume(issue)/page/year: 72,253,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 21 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JTMHA9 Journal of Tropical Medicine and Hygiene. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.10- 1907- Volume(issue)/page/year: 72,253,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 230 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 21 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***