*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX9150000
CHEMICAL NAME           : Isothiocyanic acid, 1,4-phenylenedi-
CAS REGISTRY NUMBER     : 4044-65-9
BEILSTEIN REFERENCE NO. : 2414340
REFERENCE               : 4-13-00-00174 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C8-H4-N2-S2
MOLECULAR WEIGHT        : 192.26
WISWESSER LINE NOTATION : SCNR DNCS
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Biscomate
   * Bitoscanate
   * 1,4-Diisothiocyanatobenzene
   * Isothiocyanic acid p-phenylene ester
   * Jonit
   * Phenylene-1,4-diisothiocyanate
   * Phenylene thiocyanate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JTMHA9 Journal of Tropical Medicine and Hygiene.  (Blackwell Scientific Pub.
   Ltd., POB 88, Oxford, UK)  V.10-    1907-  Volume(issue)/page/year:
   72,253,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTMHA9 Journal of Tropical Medicine and Hygiene.  (Blackwell Scientific Pub.
   Ltd., POB 88, Oxford, UK)  V.10-    1907-  Volume(issue)/page/year:
   72,253,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAZMAE Fortschritte der Arzneimittelforschung.  Progress in Drug Research.
   (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
   Secaucus, NJ 07094)  V.1-    1959-  Volume(issue)/page/year: 17,108,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAZMAE Fortschritte der Arzneimittelforschung.  Progress in Drug Research.
   (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
   Secaucus, NJ 07094)  V.1-    1959-  Volume(issue)/page/year: 17,108,1973

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***