*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NX4915520
CHEMICAL NAME           : Isoquinoline,
                          1,2,3,4-tetrahydro-3-benzylimino-6,7-dimethoxy-1-phen
                          yl-, hydrochloride, hydrate (2:2:1)
CAS REGISTRY NUMBER     : 78915-27-2
LAST UPDATED            : 199803
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C24-H24-N2-O2.Cl-H.1/2H2-O
MOLECULAR WEIGHT        : 417.93
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 3-Benzylimino-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline HCl  
   hemihydrate
   * 3-Isoquinolinamine, 1,4-dihydro-6,7-dimethoxy-1-phenyl-N-(phenylmethyl)-, 
    monohydrochloride
   * 1,2,3,4-Tetrahydro-3-benzylimino-6,7-dimethoxy-1-phenylisoquinoline HCl  
   hemihydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 144 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Behavioral - muscle contraction or spasticity
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 15,324,1981
 
                            *** END OF RECORD ***