*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NY3397000
CHEMICAL NAME           : Isoxazolo(5,4-c)pyridin-3(2H)-one,
                          4,5,6,7-tetrahydro-, monohydrobromide
CAS REGISTRY NUMBER     : 65202-63-3
LAST UPDATED            : 199606
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C6-H8-N2-O2.Br-H
MOLECULAR WEIGHT        : 221.08
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridine-3-ol hydrobromide
   * 4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3(2H)-one hydrobromide
   * THIP monohydrobromide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #0000338
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4278676
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4278676
 
                            *** END OF RECORD ***