*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NZ8177000
CHEMICAL NAME           : Kaur-16-en-15-one,
                          7-alpha,20-epoxy-1-alpha,6-beta,7,14-tetrahydroxy-,
                          (14R)-
CAS REGISTRY NUMBER     : 28957-04-2
LAST UPDATED            : 198909
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H28-O6
MOLECULAR WEIGHT        : 364.48
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   *   (1-alpha,6-beta,7-alpha,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-
     15-one
   * (14R)-7-alpha,20-Epoxy-1-alpha,6-beta,7,14-tetrahydroxykaur-16-en-15-one
   * Isodonal
   * Kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-,  
   (1-alpha,6-beta,7-alpha,14R)-
   * Oridonin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BRXXAA British Patent Document.  (U.S. Patent and Trademark Office, Foreign
   Patents, Washington, DC 20231)  Volume(issue)/page/year: #1476016
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 40 mg/L
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   9,465,1988
 
                            *** END OF RECORD ***