*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OA1196333
CHEMICAL NAME           : Keishi-bukuryo-gan
SUBSTANCE DEFINITION :
   A mixture of 5 herbal medicines, i.e., Cinnamomi Cortex, Paeoniae Radix,
   Persicae Semen, Hoelen and Moutan Cortex (3:3:3:3:3)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
LAST UPDATED            : 199603
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * TJ-25
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 23(Suppl 7),S1837,1995
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 228 gm/kg/13W-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Blood - normocytic anemia
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 23(Suppl 7),S1837,1995
 
                            *** END OF RECORD ***