*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : OB2275000 CHEMICAL NAME : Ketone, 10-(3-(dimethylamino)propyl)phenothiazin-2-yl methyl CAS REGISTRY NUMBER : 61-00-7 LAST UPDATED : 199707 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C19-H22-N2-O-S MOLECULAR WEIGHT : 326.49 WISWESSER LINE NOTATION : T C666 BN ISJ B3N1&1 EV1 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Acepromazina * Acepromazine * Acetopromazine * 2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine * Acetylpromazine * Anergan * Atsetozin * AY-57,062 * Azepromazine * 1522 CB * 10-(3-Dimethylaminopropyl)phenothiazine-3-ethylone * 1-(10-(3-(Dimethylamino)propyl)-10H-phenothiazin-2-yl)ethanone * 10-(3-Dimethylaminopropyl)phenothiazin-3-yl methyl ketone * Ethanone, 1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)- * Notensil * Plegicil * Plivafen * Promazine, acetyl- * SV-1522 * Vetranquil * WY-1172 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 24,136,1961 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,53,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RMNIBN Revista Medico-Chirurgicala. Medical-Surgical Journal. (Societatea de Medici si Naturalisti, 16 Bulevardul Independentei, Iasi, Romania) V.35- 1924- Volume(issue)/page/year: 81,105,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 130 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,53,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 59 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 115,1,1958 *** REVIEWS *** TOXICOLOGY REVIEW JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960 TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974 *** END OF RECORD ***