*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OB2450000
CHEMICAL NAME           : Ketone, 10-(3-(dimethylamino)propyl)phenothiazin-2-yl
                          methyl, maleate (1:1)
CAS REGISTRY NUMBER     : 3598-37-6
OTHER CAS REGISTRY NOS. : 2664-15-5
LAST UPDATED            : 199707
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C19-H22-N2-O-S.C4-H4-O4
MOLECULAR WEIGHT        : 442.57
WISWESSER LINE NOTATION : T C666 BN ISJ B3N1&1 EV1 &OV1U1VO
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Acepromazine maleate
   * 2-Acetyl-10-(3-(dimethylamino)propyl)phenothiazine, maleate
   * Acetylpromazine maleate (1:1)
   * Anatran
   * 10-(3-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone maleate (1:1)
   * Ethanone, 1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-,  
   (Z)-2-butenedioate (1:1)
   * Maleate acide de l'acetyl 3-dimethylamino 3-propyl-10-phenothiazine
   * Notensil maleate
   * Phenothiazine, 2-acetyl-10-(3-(dimethylamino)propyl)-, maleate
   * Plegicil maleate
   * Soprontin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 6250 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volume(issue)/page/year: 11,247,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 123,78,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,6,1989
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 113,53,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 113,53,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   19,87,1962

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X1537
       No. of Facilities: 315 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 2207 (estimated)
       No. of Female Employees: 946 (estimated)

 
                            *** END OF RECORD ***