*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : OB2450000 CHEMICAL NAME : Ketone, 10-(3-(dimethylamino)propyl)phenothiazin-2-yl methyl, maleate (1:1) CAS REGISTRY NUMBER : 3598-37-6 OTHER CAS REGISTRY NOS. : 2664-15-5 LAST UPDATED : 199707 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C19-H22-N2-O-S.C4-H4-O4 MOLECULAR WEIGHT : 442.57 WISWESSER LINE NOTATION : T C666 BN ISJ B3N1&1 EV1 &OV1U1VO COMPOUND DESCRIPTOR : Drug Human SYNONYMS/TRADE NAMES : * Acepromazine maleate * 2-Acetyl-10-(3-(dimethylamino)propyl)phenothiazine, maleate * Acetylpromazine maleate (1:1) * Anatran * 10-(3-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone maleate (1:1) * Ethanone, 1-(10-(3-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-, (Z)-2-butenedioate (1:1) * Maleate acide de l'acetyl 3-dimethylamino 3-propyl-10-phenothiazine * Notensil maleate * Phenothiazine, 2-acetyl-10-(3-(dimethylamino)propyl)-, maleate * Plegicil maleate * Soprontin *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 6250 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Cardiac - pulse rate increase, without fall in BP REFERENCE : AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 11,247,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,78,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 95 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,6,1989 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 270 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,53,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 175 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,53,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 65 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1537 No. of Facilities: 315 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2207 (estimated) No. of Female Employees: 946 (estimated) *** END OF RECORD ***