*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NY9050000
CHEMICAL NAME           : Jervine, 12-beta,13-alpha-dihydro-
CAS REGISTRY NUMBER     : 21842-58-0
LAST UPDATED            : 198909
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C26-H39-N-O3
MOLECULAR WEIGHT        : 413.66
WISWESSER LINE NOTATION : L D6 B566 CV FX LUTJ A1 OQ F-& CT56 BOX FMTJ D1 H1
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 12-beta,13-alpha-Dihydrojervine
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 75 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 26,561,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 113 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   41CIAR "Effects of Poisonous Plants on Livestock, Proceedings of a Joint
   U.S.-Australian Symposium on Poisonous Plants, Logan, UT, 1977," Keeler,
   R.F., et al. eds., New York, Academic Press, Inc., 1978
   Volume(issue)/page/year: -,409,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 150 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   41CIAR "Effects of Poisonous Plants on Livestock, Proceedings of a Joint
   U.S.-Australian Symposium on Poisonous Plants, Logan, UT, 1977," Keeler,
   R.F., et al. eds., New York, Academic Press, Inc., 1978
   Volume(issue)/page/year: -,409,1978
 
                            *** END OF RECORD ***