*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OD4025000
CHEMICAL NAME           : Lactic acid, butyl ester
CAS REGISTRY NUMBER     : 138-22-7
BEILSTEIN REFERENCE NO. : 1721597
REFERENCE               : 4-03-00-00649 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 21
MOLECULAR FORMULA       : C7-H14-O3
MOLECULAR WEIGHT        : 146.21
WISWESSER LINE NOTATION : QY1&VO4
COMPOUND DESCRIPTOR     : Primary Irritant
SYNONYMS/TRADE NAMES :
   * Butylester kyseliny mlecne
   * Butyl 2-hydroxypropanoate
   * Butyl alpha-hydroxypropionate
   * Butyl lactate
   * n-Butyl lactate
   * Propanoic acid, 2-hydroxy-, butyl ester
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Moderate
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 17,727,1979
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 17,727,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National
   Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
   Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
   Volume(issue)/page/year: 1,15,1974
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 11 gm/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 17,727,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 17,727,1979

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 30 mg/m3 (5 ppm)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 1 ppm (5 mg/m3)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year: 3,33,1971

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 5 ppm (25 mg/m3) JAN 1993
   
   OEL-BELGIUM:TWA 5 ppm (30 mg/m3) JAN 1993
   
   OEL-DENMARK:TWA 5 ppm (25 mg/m3) JAN 1993
   
   OEL-FINLAND:TWA 1 ppm (6 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993
   
   OEL-FRANCE:TWA 5 ppm (25 mg/m3) JAN 1993
   
   OEL-THE NETHERLANDS:TWA 5 ppm (25 mg/m3) JAN 1993
   
   OEL-SWITZERLAND:TWA 5 ppm (30 mg/m3) JAN 1993
   
   OEL-UNITED KINGDOM:TWA 5 ppm (25 mg/m3) JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO n-BUTYL LACTATE-air:10H TWA 5 ppm
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M1128
       No. of Facilities: 242 (estimated)
       No. of Industries: 8
       No. of Occupations: 10
       No. of Employees: 3107 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M1128
       No. of Facilities: 170 (estimated)
       No. of Industries: 9
       No. of Occupations: 15
       No. of Employees: 5342 (estimated)
       No. of Female Employees: 1381 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***