*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OE9800000
CHEMICAL NAME           : Lauric acid
CAS REGISTRY NUMBER     : 143-07-7
BEILSTEIN REFERENCE NO. : 1099477
REFERENCE               : 4-02-00-01082 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C12-H24-O2
MOLECULAR WEIGHT        : 200.36
WISWESSER LINE NOTATION : QV11
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Natural Product
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * C-1297
   * Dodecanoic acid
   * n-Dodecanoic acid
   * Dodecoic acid
   * Duodecylic acid
   * Hydrofol acid 1255
   * Hydrofol acid 1295
   * Hystrene 9512
   * Laurostearic acid
   * Neo-fat 12
   * Neo-fat 12-43
   * Ninol AA62 Extra
   * 1-Undecanecarboxylic acid
   * Wecoline 1295
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg
REACTION SEVERITY       : Mild
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 6(3),321,1987
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg
REACTION SEVERITY       : Mild
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 6(3),321,1987
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FDRLI* Food & Drug Research Laboratories, Inc., Papers.  (P.O. Box 107, Rt.
   17C, Waverly, NY 14892-0107)  Volume(issue)/page/year: 123,-,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 131 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   18,141,1961
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 333 gm/kg/13W-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - fluid intake
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 16,519,1978
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 108 gm/kg/15W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   APMIAL Acta Pathologica et Microbiologica Scandinavica.  (Copenhagen,
   Denmark)  V.1-77, 1924-69.  For publisher information, see ACPADQ.
   Volume(issue)/page/year: 46,51,1959
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 10 mg/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 294,263,1981

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 21,100,1960

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84696
       No. of Facilities: 1256 (estimated)
       No. of Industries: 14
       No. of Occupations: 34
       No. of Employees: 14960 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 84696
       No. of Facilities: 4690 (estimated)
       No. of Industries: 51
       No. of Occupations: 50
       No. of Employees: 77970 (estimated)
       No. of Female Employees: 17300 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***