*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OH2850000
CHEMICAL NAME : Leucine, L-
CAS REGISTRY NUMBER : 61-90-5
LAST UPDATED : 199706
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C6-H13-N-O2
MOLECULAR WEIGHT : 131.20
WISWESSER LINE NOTATION : QVYZ1Y1&1 -L
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* alpha-Aminoisocaproic acid
* 2-Amino-4-methylpentanoic acid
* alpha-Amino-gamma-methylvaleric acid
* Leucin
* Leucine
* L-Leucine
* Norvaline, 4-methyl-
* Valeric acid, 2-amino-4-methyl-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5379 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year:
58,253,1955
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
Volume(issue)/page/year: 40,313,1898
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 138 gm/kg
SEX/DURATION : female 5-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 74,93,1961
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 90 mg/kg
SEX/DURATION : female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 5,77,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 90 mg/kg
SEX/DURATION : female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year:
56,37,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 90 mg/kg
SEX/DURATION : female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year:
56,37,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 60 mg/kg
SEX/DURATION : female 6-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year:
56,37,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 60 mg/kg
SEX/DURATION : female 6-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
WIMJAD West Indian Medical Journal. (Univ. of the West Indies, Faculty of
Medicine, Kingston 7, Jamaica) V.1- 1951- Volume(issue)/page/year:
18,34,1969
** MUTATION DATA **
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81818
No. of Facilities: 53 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 750 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81818
No. of Facilities: 1037 (estimated)
No. of Industries: 4
No. of Occupations: 18
No. of Employees: 21979 (estimated)
No. of Female Employees: 16153 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***